Perlecan on Vascular Smooth Muscle Cell Response to Arterial Injury
نویسندگان
چکیده
Heparan Sulfate Side Chains have a Critical Role in the Inhibitory Effects of 1 Perlecan on Vascular Smooth Muscle Cell Response to Arterial Injury 2 *Lara Gotha MSc, *Sang Yup Lim MD, PhD Azriel B. Osherov MD, Rafael Wolff 3 MD, Beiping Qiang MD, PhD, Ilana Erlich MD, Nafiseh Nili PhD, Sivaram 4 Pillarisetti PhD, Ya-Ting Chang MD, Phan-Kiet Tran MD, PhD, Karl Tryggvason 5 PhD, Ulf Hedin MD, PhD, Karin Tran-Lundmark MD, PhD, Suzanne L. Advani BSc, 6 Richard E. Gilbert MD, PhD, and Bradley H. Strauss MD, PhD 7 8 Schulich Heart Program, Sunnybrook Health Sciences Centre, Keenan Research Centre 9 in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, 10 Toronto, Ontario, Canada. Reddy US Therapeutics, Norcross, Georgia, USA. 4 Dept of 11 Pediatric Cardiac Surgery, Skane University Hospital, Lund, Sweden, Dept of Molecular 12 Medicine and Surgery, Karolinska Institute, Stockholm, Sweden, Korea University 13 Ansan Hospital, Ansan, Korea; Current Address: Department of Cardiology, Barzilai 14 Medical Center, Ashkelon, Ben-Gurion University, Israel. 15 • co-primary authors 16 The study was funded by the Canadian Institute of Health Research and the Canada 17 Research Chair Program. Dr. Richard Gilbert is the Canada Research Chair in Diabetes 18 Complications. Drs Tran, Tran-Lundmark and Hedin were funded by Princess Lovisas’ 19 Research Foundation, Swedish Heart-Lung Foundation and Swedish Research Council. 20 Address for correspondence: Dr. Bradley H. Strauss, Reichmann Chair in Cardiovascular 21 Research, Schulich Heart Center, Sunnybrook Health Sciences Centre, D-406, 2075 22 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5 Telephone: (416) 480-6066, Fax: 23 (416) 480-6174, email:[email protected] 24 Words: 5737 25 Articles in PresS. Am J Physiol Heart Circ Physiol (May 23, 2014). doi:10.1152/ajpheart.00654.2013
منابع مشابه
Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury.
Perlecan is a proteoglycan composed of a 470-kDa core protein linked to three heparan sulfate (HS) glycosaminoglycan chains. The intact proteoglycan inhibits the smooth muscle cell (SMC) response to vascular injury. Hspg2(Δ3/Δ3) (MΔ3/Δ3) mice produce a mutant perlecan lacking the HS side chains. The objective of this study was to determine differences between these two types of perlecan in modi...
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Perlecan is a large heparan sulfate proteoglycan (HSPG), which is a major component of the vessel wall. In relation to vascular biology, perlecan has been shown to be a potent inhibitor of smooth muscle cell (SMC) activity. In vivo experiments in animal models of arterial injury have shown that perlecan may inhibit thrombosis and intimal hyperplasia. On the other hand, perlecan has been shown t...
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